![]() ![]() Fouling is typically quantified as decreased flux at constant TMP or increased TMP at constant flux. The most common operational challenge for MF processes is filter fouling due to deposition of insoluble material on the membrane surface or inside membrane pores, which increases flow resistance (Marichal-Gallardo and Alvarez 2012 van Reis and Zydney 2007). However, performance upon scale-up is difficult to predict, heavily dependent on the nature of the feedstock, and often must be optimized empirically (Roush and Lu 2008 Saxena et al. Most commonly, MF unit operations are scaled on constant load factor (volume or mass per filter area), membrane channel geometry, path length, crossflow velocity, and transmembrane pressure (TMP) (Marichal-Gallardo and Alvarez 2012). Successful scale-up is a key challenge in implementation of microfiltration processes. ![]() MF processes have been classically employed in harvest and primary recovery, whereas UF processes have been largely used as polishing steps for buffer exchange or concentration (Marichal-Gallardo and Alvarez van Reis and Zydney 2001). TFF is typically categorized as microfiltration (MF pore sizing in microns) or ultrafiltration (UF pore sizing in nominal molecular weight limit). Tangential flow filtration (TFF) is a robust and versatile separation technique used in biopharmaceutical manufacturing. The present invention relates to the use of two tandem microfiltration (MF) steps in a process for making recombinant insulin. BACKGROUND OF THE INVENTION (1) Field of the Invention ![]()
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